Dichloromethane → 2,6-Dihydroxybenzonitrile

HRID 660621

反応式

HRID 660621 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:3]=1[CH:4]=O.S(O)(O)(=O)=O.[NH2:16]O.C(Cl)Cl.C([O-])(O)=O.[Na+]>O>[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:3]=1[C:4]#[N:16]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 159255Hydroxylamine, sulfate (1:1)HCID 516892Sodium BicarbonateHCID 102858012,6-Dihydroxybenzaldehyde

生成物 1

HCID 937912,6-Dihydroxybenzonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2,6-dihydroxybenzaldehyde (300 mg, 2.17 mmol) and hydroxylamine sulfate (758 mg, 6.51 mmol) in water (30 mL) is stirred at RT for 45 min. Methylene chloride (60 mL) is added followed by NaHCO3 (911 mg, 10.85 mmol) and the mixture is stirred at RT for 30 min. The organic phase is separated and dried over sodium sulfate and the solvent removed under reduced pressure to give the title compound as a pale yellow solid.

後処理

  1. stirringthe mixture is stirred at RT for 30 min
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-debdfd5d2d5f45438a483499e7fa3ccd
出典データセット
uspto-grants-2011_12
特許番号
US08084448B2

関連ノート

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