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Potassium periodate → 7-Acetoxy-8-methoxycoumarin-6-acetaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium periodate | HCID 516896 | — |
| 反応物 | 7-Acetoxy-6-allyl-8-methoxycoumarin | HCID 21814501 | — |
| 触媒 | Osmium Tetroxide | HCID 30318 | — |
| 溶媒 | Water ethylacetate | HCID 22728543 | — |
| 生成物 | 7-Acetoxy-8-methoxycoumarin-6-acetaldehyde | HCID 53767256 | — |
反応手順
A solution of 0.274g. (0.001 mole) of 7-acetoxy-6-allyl-8-methoxycoumarin in 10 ml. EtOAc/water, 1:1 was treated with 0.8 g. (.0033 mole) of potassium periodate and 0.5 ml. of a 10% aqueous solution of osmium tetroxide (10 mg. OsO4 /ml H2O). The reactants were stirred at 25° for 5.0 hours. The organic layer was separated, and the aqueous phase was further extracted with ethyl acetate. The organic extracts were combined, dried over sodium sulfate, and evaporated to yield pure 7-acetoxy-8-methoxycoumarin-6-acetaldehyde as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04130568 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-114648409cd6424fb94fc756031f3ca9 |
| 出典メモ | uspto-grants-1978_12 |