Sodium Carbonate → 5-[2-Benzyloxy-4-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Carbonate	HCID 10340	—
反応物	1-(Triisopropylsilyl)pyrrole-3-boronic acid	HCID 2763303	—
反応物	5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one	HCID 68838643	—
触媒	HCID 178418397	HCID 178418397	—
溶媒	1,2-Dimethoxyethane	HCID 8071	—
生成物	5-[2-Benzyloxy-4-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one	HCID 68839429	—

反応条件

温度	120 °C

反応手順

To a solution of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (100 mg, 0.225 mmol) in DME (5 mL) is added 1-triisopropylsilylpyrrole-3-boronic acid (120 mg, 0.450 mmol), Pd(PPh3)4 (27 mg, 0.023 mmol) and 0.5 mL of Na2CO3 (2M aqueous solution) and the mixture is heated in a microwave apparatus at 120° C. for 5 min. The mixture is concentrated under reduced pressure and the residue purified by reverse phase MPLC using a gradient of 10-50% MeCN/water as eluent to afford the title compound: (M−1)−=538.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08084448B2
出典データセット	uspto-grants-2011_12
ORD ID	ord-5af0f2be0f7847ddb8a0b6853568e1d2
出典メモ	uspto-grants-2011_12