関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzyl 2-(benzyloxy)-4-chlorobenzoate | HCID 66989997 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(Benzyloxy)-4-chlorobenzoic acid | HCID 22452154 | — |
反応手順
To a solution of 2-benzyloxy-4-chlorobenzoic acid benzyl ester in EtOH (500 mL) is added 1N NaOH (100 mL) and the mixture is stirred at 60° C. for 24 h. The mixture is allowed to cool to RT and is acidified with 1N HCl. The volume of the solution is reduced to 250 mL and the resulting precipitate is filtered, washed with water and dried to give the title compound as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08084448B2 |
|---|
| 出典データセット | uspto-grants-2011_12 |
|---|
| ORD ID | ord-838b99b9482146618fe143d268dbdd53 |
|---|
| 出典メモ | uspto-grants-2011_12 |
|---|
