Hydrochloric Acid → 2-(Benzyloxy)-4-chlorobenzoic acid

HRID 660821

反応式

HRID 660821 の反応式
C([O:8][C:9](=[O:25])[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C1C=CC=CC=1.[OH-].[Na+].Cl>CCO>[CH2:18]([O:17][C:11]1[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=1[C:9]([OH:25])=[O:8])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66989997Benzyl 2-(benzyloxy)-4-chlorobenzoate

生成物 1

HCID 224521542-(Benzyloxy)-4-chlorobenzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To a solution of 2-benzyloxy-4-chlorobenzoic acid benzyl ester in EtOH (500 mL) is added 1N NaOH (100 mL) and the mixture is stirred at 60° C. for 24 h. The mixture is allowed to cool to RT and is acidified with 1N HCl. The volume of the solution is reduced to 250 mL and the resulting precipitate is filtered, washed with water and dried to give the title compound as an off-white solid.

後処理

  1. temperatureto cool to RT
  2. filtrationthe resulting precipitate is filtered
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-838b99b9482146618fe143d268dbdd53
出典データセット
uspto-grants-2011_12
特許番号
US08084448B2

関連ノート

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