Stannous Chloride → 2-(Benzyloxy)-4-fluoroaniline

HRID 660827ノート

反応式

HRID 660827 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl>CCO>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 24479Stannous ChlorideHCID 110969082-(Benzyloxy)-4-fluoro-1-nitrobenzene

生成物 1

HCID 167713362-(Benzyloxy)-4-fluoroaniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 2-benzyloxy-4-fluoro-1-nitrobenzene (2.4 g, 10 mmol) in EtOH (20 mL) is added SnCl2 (9.45 g, 50 mmol) and the suspension is stirred at RT overnight. The solvent is removed under reduced pressure and the residue is adjusted to pH >8. The aqueous layer is extracted with EtOAc and the combined organic layers are washed with water and brine, then dried over MgSO4 and filtered. The solvent is removed under reduced pressure to give the product as a red oil.

後処理

  1. customThe solvent is removed under reduced pressure
  2. extractionThe aqueous layer is extracted with EtOAc
  3. washthe combined organic layers are washed with water and brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-75440715f8304066b8180cb26d54d7b4
出典データセット
uspto-grants-2011_12
特許番号
US08084448B2

反応ノート

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