Methanol → 5-(4-chlorophenyl)-1-cyclopropyl-1,3-dihydro-2H-imidazol-2-one
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][NH:10][C:11]([NH:13][CH:14]2[CH2:16][CH2:15]2)=[O:12])=[CH:4][CH:3]=1.CO>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]([CH:14]3[CH2:16][CH2:15]3)[C:11](=[O:12])[NH:10][CH:9]=2)=[CH:4][CH:3]=1参加物
4
実験手順
1525 mg (6.035 mmol) of N-[2-(4-chlorophenyl)-2-oxoethyl]-N′-cyclopropylurea from Example 113A are suspended in 25 ml of concentrated hydrochloric acid, treated with 25 ml methanol and stirred for one hour at room temperature. The reaction mixture is evaporated to dryness and the residue purified by flash chromatography on silica gel (eluent: dichloromethane/methanol 100:1, then 50:1). 1300 mg (90% of theory) of the target compound are obtained.
後処理
- customThe reaction mixture is evaporated to dryness
- customthe residue purified by flash chromatography on silica gel (eluent
- custom1300 mg (90% of theory) of the target compound are obtained
出典と根拠
- ORDレコード
- ord-ddbf949385824259a9de6526d3fe0f94
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084481B2
反応ノート
読み込み中…