Hydrochloric Acid → [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

HRID 660875ノート

反応式

HRID 660875 の反応式
C([O:3][C:4](=[O:22])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=2)[N:8]([CH:18]2[CH2:20][CH2:19]2)[C:7]1=[O:21])C.[OH-].[K+].Cl>CO>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:8]([CH:18]3[CH2:20][CH2:19]3)[C:7](=[O:21])[N:6]([CH2:5][C:4]([OH:22])=[O:3])[CH:10]=2)=[CH:12][CH:13]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58012242Ethyl [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate

生成物 1

HCID 58011674[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

502 mg (1.28 mmol) of ethyl[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 124A are placed in 0.94 ml methanol, treated with 0.34 ml 20% aqueous potassium hydroxide and stirred overnight at room temperature. It is adjusted to pH 3 with 1 N hydrochloric acid, the resulting precipitate recovered by filtration, and the product washed with water and dried in vacuo. 369 mg (80% of theory) of the target compound, which is reacted without further purification, are thus obtained.

後処理

  1. filtrationthe resulting precipitate recovered by filtration
  2. washthe product washed with water
  3. customdried in vacuo
  4. custom369 mg (80% of theory) of the target compound, which is reacted without further purification
  5. customare thus obtained

出典と根拠

ORDレコード
ord-99b319155a4349a5a56dc243f5c647cf
出典データセット
uspto-grants-2011_12
特許番号
US08084481B2

反応ノート

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