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Amantadine → N-(4-nitrophenyl)adamantan-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Amantadine | HCID 2130 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Hexamethylphosphoramide | HCID 12679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(4-nitrophenyl)adamantan-1-amine | HCID 12510269 | — |
反応手順
A mixture of 1.51 g. (0.01 mole) of 1-adamantamine, 1.41 g. p-fluoronitrobenzene and 1.38 g. K2CO3 in 10 ml. HMPA was stirred overnight in an oil bath at 135°. The mixture was allowed to cool, diluted with H2O and extracted thoroughly with C6H6. The organic layer was washed in turn with H2O and brine and taken to dryness. The waxy residue was recrystallized twice from Me2CO:cyclohexane to give 1.82 g. (67%) of N,1-adamantyl-p-nitroaniline, m.p. 188°-189°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04130561 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-17014710960f4dae85ffe803714eb7bb |
| 出典メモ | uspto-grants-1978_12 |