4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene → Methyl 5-[3-fluoro-4-(trifluoromethoxy)phenyl]nicotinate
反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[C:4]([F:13])[CH:3]=1.CC1(C)C(C)(C)OB([C:22]2[CH:23]=[N:24][CH:25]=[C:26]([CH:31]=2)[C:27]([O:29][CH3:30])=[O:28])O1>>[F:13][C:4]1[CH:3]=[C:2]([C:22]2[CH:23]=[N:24][CH:25]=[C:26]([CH:31]=2)[C:27]([O:29][CH3:30])=[O:28])[CH:7]=[CH:6][C:5]=1[O:8][C:9]([F:12])([F:11])[F:10]参加物
3
実験手順
According to General Method 1A, 8.0 g (30.9 mmol) of 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene and 20.13 g (77.22 mmol) of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate were reacted. Yield: 8.02 g (69% of theory)
後処理
- customwere reacted
出典と根拠
- ORDレコード
- ord-635e5e43acb7453d8990aae2780ddf59
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084469B2
反応ノート
読み込み中…