5-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-one → 2-(4-Hydroxy-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic Acid Diethyl Ester

HRID 66132

反応式

HRID 66132 の反応式
[C:1]([C:8]([O:10][CH2:11][CH3:12])=[O:9])#[C:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:13][C:14]1[CH:20]=[CH:19][C:18](=[O:21])[C:17]([OH:22])=[CH:16][CH:15]=1>C(O)C>[CH2:6]([O:5][C:3](=[O:4])[C:2]([NH:13][C:14]1[CH:20]=[CH:19][C:18](=[O:21])[C:17]([OH:22])=[CH:16][CH:15]=1)=[CH:1][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:7]

参加物

4

反応物 2

HCID 234505-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-oneHCID 69803Diethyl acetylenedicarboxylate

生成物 1

HCID 867362102-(4-Hydroxy-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic Acid Diethyl Ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of diethyl acetylenedicarboxylate (183.5 g) and 5-amino-2-hydroxy-2,4,6-cycloheptatriene-1-one [147.5 g, described by T. Nozoe et al., Science Repts. Tokoku Univ., First ser., 35, 274(1952)] in ethanol (2,700 ml) is stirred at room temperature for 16 hours. The mixture is filtered and the precipitate is crystallized from ethanol to obtain crystals of the title compound, mp 108.5° C.

後処理

  1. filtrationThe mixture is filtered
  2. customthe precipitate is crystallized from ethanol

出典と根拠

ORDレコード
ord-10aa283fe0b041468ebb0880110df018
出典データセット
uspto-grants-1978_12
特許番号
US04130649

関連ノート

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