Hydrochloric Acid → 6-Amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic Acid

反応式

C([O:3][C:4]([C:6]1[NH:11][C:10]2[CH:12]=[CH:13][C:14](=[O:18])[C:15]([NH2:17])=[CH:16][C:9]=2[C:8](=[O:19])[CH:7]=1)=[O:5])C.[OH-].[K+].Cl>>[NH2:17][C:15]1[C:14](=[O:18])[CH:13]=[CH:12][C:10]2[NH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8](=[O:19])[C:9]=2[CH:16]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 14797Potassium Hydroxide

HCID 537797806-amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester

生成物 1

HCID 227556146-Amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic Acid

実験手順

A mixture of 6-amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (0.73 g, described in Example 3) and 2N potassium hydroxide (15 ml) is stirred at room temperature for 16 hr. Hydrochloric acid (10%) is added until the solution is acidic. The crystalline precipitate is collected and washed with water and acetone to give the title compound, mp > 270° C.