Hydrochloric Acid → 4,7-Dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid
反応式
C([O:3][C:4]([C:6]1[N:11]([CH3:12])[C:10]2[CH:13]=[CH:14][C:15](=[O:20])[C:16]([O:18][CH3:19])=[CH:17][C:9]=2[C:8](=[O:21])[CH:7]=1)=[O:5])C.[OH-].[K+].Cl>>[O:21]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[N:11]([CH3:12])[C:10]2[CH:13]=[CH:14][C:15](=[O:20])[C:16]([O:18][CH3:19])=[CH:17][C:9]1=2参加物
4
実験手順
A mixture of 4,7-dihydro-4,7-dioxo-6-methoxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (2.89 g, described in Example 7) and 1N potassium hydroxide (11 ml) is stirred at room temperature for 16 hr. Hydrochloric acid (10%) is added until the solution is acidic. The precipitate is collected, washed with water and acetone and crystallized from acetic acid to obtain crystals of the title compound, mp > 250° C.