Methane → 4,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

HRID 66148ノート

反応式

HRID 66148 の反応式
C([O:3][C:4]([C:6]1[N:11](CCC)[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])C.Cl.C>>[O:25]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:11][C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]1=2

参加物

4

反応物 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 53707130HCID 53707130、化合物

生成物 1

HCID 227556674,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

実験手順

A mixture of 4,7-dihydro-4,7-dioxo-6-propoxy-1-propyl-1H-cyclohepta[b]pyridine-2-carboxlic acid ethyl ester (3.8 g, described in Example 22) and 19% hydrochloric acid (113 ml) is refluxed for 30 minutes. Charcoal is added and the hot mixture is filtered. The filtrate is cooled to room temperature and the crystalline precipitate is collected and dried to obtain the title compound, mp > 250° C.

後処理

  1. temperatureis refluxed for 30 minutes
  2. filtrationthe hot mixture is filtered
  3. customthe crystalline precipitate is collected
  4. customdried

出典と根拠

ORDレコード
ord-768ff5e905c442d292fe4bdf6acf1096
出典データセット
uspto-grants-1978_12
特許番号
US04130649

反応ノート

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