Cyclohexylamine → 2-[2-Phenyl-2-(diethylamino)-ethenyl]-3,4,5,6-tetrahydropyridine

HRID 66167ノート

反応式

HRID 66167 の反応式
C(O[C:4]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5][C:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]=1)C.F[B-](F)(F)F.C1(N)CCCCC1.C1(C(NC2CCCCC2)=[CH:37][C:38]2CC[CH2:41][CH2:40][N:39]=2)C=CC=CC=1.CS([O-])(=O)=O>C(NCC)C>[C:12]1([C:4]([N:39]([CH2:40][CH3:41])[CH2:38][CH3:37])=[CH:5][C:6]2[CH2:11][CH2:10][CH2:9][CH2:8][N:7]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

6

反応物 4

HCID 7965CyclohexylamineHCID 85257MethanesulfonateHCID 867362192-(2-Ethoxy-2-phenyl-ethenyl)-3,4,5,6-tetrahydropyridine tetrafluoroborate2 回HCID 178463269HCID 178463269、化合物

生成物 1

HCID 539011482-[2-Phenyl-2-(diethylamino)-ethenyl]-3,4,5,6-tetrahydropyridine

試薬・触媒・溶媒 1

HCID 8021Diethylamine溶媒

実験手順

Analogously to Example 1, there is obtained, starting with 9.5 g of 2-(2-ethoxy-2-phenyl-ethenyl)-3,4,5,6-tetrahydropyridine-tetrafluoroborate and 30 ml of cyclohexylamine, 2-[(2-phenyl-2-(cyclohexylamino)-ethenyl]-3,4,5,6-tetrahydropyridine, and from this its (1:1)-methanesulphonate, m.p. 172°-173°; and starting with 9.5 g of 2-(2-ethoxy-2-phenyl-ethenyl)-3,4,5,6-tetrahydropyridine-tetrafluoroborate and 30 ml of diethylamine, is obtained 2-[2-phenyl-2-(diethylamino)-ethenyl]-3,4,5,6-tetrahydropyridine, and from this its (1:1)-fumarate, m.p. 169°-170° (from isopropanol).

後処理

  1. customAnalogously to Example 1, there is obtained

出典と根拠

ORDレコード
ord-16d427ede03343c3b3d0734e3049c9e8
出典データセット
uspto-grants-1978_12
特許番号
US04130652

反応ノート

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