1,4,7,10-Tetraazacyclododecane → Qvd35D4RP3

HRID 66220

反応式

HRID 66220 の反応式
[NH:1]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:13]OC(OC)N(C)C>C1C=CC=CC=1>[N:1]12[CH:13]3[N:4]([CH2:5][CH2:6][N:7]3[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[CH2:3][CH2:2]2

参加物

4

反応物 2

HCID 649631,4,7,10-TetraazacyclododecaneHCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 10702593Qvd35D4RP3

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

In a manner similar to that of Example 2 (A), 5.00 g (29.1 mmol) of 1,4,7,10-tetraazacyclododecane, 3.46 g of dimethylformamide dimethyl acetal and 50 ml of dry benzene gave 5.00 g of colorless liquid, bp 88.5°-90° (0.30 mm). Analytically pure 1,4,7,10-tetraazatricyclo[5.5.1.04,13 ]tridecane was obtained by distillation of this material through a spinning band column, bp 82°-83° (two fractions) (0.25 mm) One fraction had nD25 = 1.5331. The other fraction was analyzed.

出典と根拠

ORDレコード
ord-8cb543ec60764a058d57cf1a2f4aa7b6
出典データセット
uspto-grants-1978_12
特許番号
US04130715

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