Hydrochloric Acid → Ethyl 3,4-dichlorophenylacetate

HRID 66284

反応式

HRID 66284 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH2:14](O)[CH3:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 798743,4-Dichlorophenylacetic acid

生成物 1

HCID 2737422Ethyl 3,4-dichlorophenylacetate

実験手順

A solution of 59.5 g of 3,4-dichlorophenylacetic acid in 500 ml of absolute ethanol is saturated with anhydrous hydrogen chloride and then heated at reflux for 2 hours. The mixture is concentrated under reduced pressure to 200 ml, diluted with 200 ml of water and neutralized with concentrated ammonium hydroxide. This aqueous mixture is extracted 3 times with chloroform. Concentration and decolorization of the chloroform extracts gives ethyl 3,4-dichlorophenylacetate as a yellow oil.

後処理

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. concentrationThe mixture is concentrated under reduced pressure to 200 ml
  4. additiondiluted with 200 ml of water and neutralized with concentrated ammonium hydroxide
  5. extractionThis aqueous mixture is extracted 3 times with chloroform
  6. concentrationConcentration and decolorization of the chloroform

出典と根拠

ORDレコード
ord-b9ade33be6744171a856e8867365fe03
出典データセット
uspto-grants-1978_12
特許番号
US04131611

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