関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sec-Butylamine | HCID 24874 | — |
| 反応物 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| 溶媒 | Diisopropyl Ether | HCID 7914 | — |
| 生成物 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one | HCID 22754738 | — |
反応手順
A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04131674 |
|---|
| 出典データセット | uspto-grants-1978_12 |
|---|
| ORD ID | ord-023d2509928949a9bbadc17115bc650a |
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| 出典メモ | uspto-grants-1978_12 |
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