Dichloromethane → 3-cyano-N-[2-(4-fluoro-2-methylphenyl)-4-(tetrahydro-2H-pyran-2-yloxy)butyl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide

反応式

[C:21](#[N:22])[c:23]1[cH:24][c:25]([C:33](=[O:34])[OH:35])[c:26]2[c:31]([cH:32]1)[CH2:30][CH2:29][CH2:28][CH2:27]2.[CH:36]1([N:37]=[C:38]=[N:39][CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]2)[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]1.[Cl:51][CH2:52][Cl:53].[F:1][c:2]1[cH:3][c:4]([CH3:20])[c:5]([CH:8]([CH2:9][NH2:10])[CH2:11][CH2:12][O:13][CH:14]2[O:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][c:4]([CH3:20])[c:5]([CH:8]([CH2:9][NH:10][C:33]([c:25]2[cH:24][c:23]([C:21]#[N:22])[cH:32][c:31]3[c:26]2[CH2:27][CH2:28][CH2:29][CH2:30]3)=[O:34])[CH2:11][CH2:12][O:13][CH:14]2[O:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[cH:6][cH:7]1