関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Diethylcarbamoyl chloride | HCID 6916 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-hydroxyisoindolin-1-one | HCID 19900408 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-diethylaminocarbonyloxy-isoindolin-1-one | HCID 22754741 | 57.5% |
反応手順
The procedure of Example 21 is followed but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-isoindolin-1-one (6.2 g.) in methylene chloride (300 cc.), diethylcarbamoyl chloride (8.15 g.), triethylamine (8.4 cc.) and pyridine (30 cc.). Water (250 cc.) is added to the reaction mixture after it has been stirred for 48 hours at a temperature of about 20° C. The precipitate formed is filtered off and recrystallised from diisopropyl ether (800 cc.) to give 2-(7-chloro-1,8-naphthyridin-2-yl)-3-diethylaminocarbonyloxy-isoindolin-1-one (4.7 g.) melting at 142°-144° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04131674 |
|---|
| 出典データセット | uspto-grants-1978_12 |
|---|
| ORD ID | ord-5c9a789c3a32422c83bb9b1833d78db1 |
|---|
| 出典メモ | uspto-grants-1978_12 |
|---|
