Hydrogen Peroxide → 2-(2-Fluorophenyl)oxazolo[4,5-b]pyridine 4-oxide

HRID 66350ノート

反応式

HRID 66350 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:11]([N:16]=1)=[N:12][CH:13]=[CH:14][CH:15]=2.[OH:17]O>C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:11]([N:16]=1)=[N+:12]([O-:17])[CH:13]=[CH:14][CH:15]=2

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 1971814Oxazolo(4,5-b)pyridine, 2-(2-fluorophenyl)-

生成物 1

HCID 227547722-(2-Fluorophenyl)oxazolo[4,5-b]pyridine 4-oxide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 1 g. of 2-(2-fluorophenyl)oxazolo[4,5-b]pyridine (from Example 6) in 10 ml. of acetic acid was treated with 2 ml. of 30% hydrogen peroxide and heated on the steam bath for 16 hours. After cooling the mixture was diluted with ice-water. The precipitate was collected and recrystallized from dioxane-ether to give 2-(2-fluorophenyl)oxazolo[4,5-b]pyridine-4-oxide, m.p. 214°-216° C.

後処理

  1. temperatureAfter cooling the mixture
  2. customThe precipitate was collected
  3. customrecrystallized from dioxane-ether

出典と根拠

ORDレコード
ord-556938ba02a94028ad70f9e9223dd3e9
出典データセット
uspto-grants-1978_12
特許番号
US04131677

反応ノート

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