化工社化工社 化学情報印刷レポート · 研究参考用
Benzoic Acid → 5-Methyl-2-phenyloxazolo[4,5-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | 2-Amino-6-methylpyridin-3-ol | HCID 88500 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | 5-Methyl-2-phenyloxazolo[4,5-b]pyridine | HCID 19990483 | — |
反応手順
A mixture of 1.25 g. of 2-amino-3-hydroxy-6-methylpyridine, 6 g. of polyphosphoric acid and 2.0 g. benzoic acid was heated at 190°-200° C. for 10 minutes. The cooled mixture was diluted with water and basified with solid sodium bicarbonate. The resulting precipitate was collected and recrystallized from ether to give 5-methyl-2-phenyloxazolo[4,5-b]pyridine, m.p. 148°-149° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04131677 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-0d9bf10312bb454daf6de91028c22df8 |
| 出典メモ | uspto-grants-1978_12 |