Acetone → 2-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

HRID 66357ノート

反応式

HRID 66357 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2.CC(C)=[O:20].I([O-])(=O)(=O)=O.[Na+]>O>[CH3:1][S:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:20]

参加物

5

反応物 3

HCID 180AcetoneHCID 124613832-(2-(Methylthio)phenyl)oxazolo[4,5-b]pyridineHCID 23667635Sodium periodate

生成物 1

HCID 227547742-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 0.5 g. of 2-(2-methylthiophenyl)oxazolo[4,5-b]pyridine in 50 ml. of acetone was treated with 3 g. of sodium metaperiodate. After stirring over the weekend at room temperature, the mixture was diluted with 30 ml. of water. The acetone was distilled out and the resulting precipitate was recrystallized to give 2-(2-methylsulfinylphenyl)oxazolo[4,5-b]pyridine, m.p. 153.5°-155.5° C.

後処理

  1. additionthe mixture was diluted with 30 ml
  2. distillationThe acetone was distilled out
  3. customthe resulting precipitate was recrystallized

出典と根拠

ORDレコード
ord-548d223cad3b4458973ef2116fdf6cae
出典データセット
uspto-grants-1978_12
特許番号
US04131677

反応ノート

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