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Methanol → 3-Amino-5-nitropyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Sodium sulfide nonahydrate | HCID 73972 | — |
| 反応物 | 2(1H)-Pyridinone, 3,5-dinitro- | HCID 76324 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Amino-5-nitropyridin-2(1H)-one | HCID 22754782 | — |
反応手順
A solution of 5.5 g. of 3,5-dinitro-2-pyridone in 200 ml. of methanol was adjusted to pH 8 with ammonium hydroxide. At 60-65° C., there was added slowly a solution of 10.8 g. of sodium sulfide nonahydrate in 30 ml. of water. After 1 hour at 60-65° C. the solvent was evaporated and the residue was extracted with hot benzene and acetic acid to neutralize any sodium salt. The benzene was decanted and cooled to give a precipitate. Recrystallization from methanol gave 3-amino-5-nitro-2-pyridone, m.p. 200°-201° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04131677 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-2fa70162e10541fb943089f50b6b7a29 |
| 出典メモ | uspto-grants-1978_12 |