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Sulfuric Acid → 2-Hydroxy-6-methyl-3-nitropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-Amino-6-methyl-3-nitropyridine | HCID 226028 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Hydroxy-6-methyl-3-nitropyridine | HCID 543029 | — |
反応手順
A solution of 24 g. of 2-amino-6-methyl-3-nitropyridine in 25 ml. of concentrated sulfuric acid and 380 ml. of water was cooled to 0° C. and treated with 11 g. of sodium nitrite in 25 ml. of water. The temperature spontaneously rose to 45° C. After cooling, the precipitate of 6-methyl-3-nitro-2-pyridone was collected (m.p. 222°-223° C.) and used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04131677 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-3ae5f561ecfb4a0585066f857d993c18 |
| 出典メモ | uspto-grants-1978_12 |