関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromophenol | HCID 7808 | — |
| 反応物 | (R)-1-Boc-3-methylpiperazine | HCID 2756811 | — |
| 試薬 | Potassium tert-butoxide | HCID 23665647 | — |
| 触媒 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 触媒 | Bis(tri-tert-butylphosphine)palladium(0) | HCID 2734558 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | tert-butyl (3R)-4-(4-hydroxyphenyl)-3-methylpiperazine-1-carboxylate | HCID 70873444 | 0% |
反応手順
A mixture of (R)-tert-butyl 3-methylpiperazine-1-carboxylate (0.025 g, 0.12 mmol), 4-bromophenol (0.043 g, 0.25 mmol), bis(tri-t- butylphosphine)palladium(0) (6.38 mg, 0.01 mmol) and [Reactants] in THF (2 mL) was flushed with nitrogen and sealed into a microwave tube. The reaction was heated to 100 °C for 20 minutes in the microwave reactor and cooled to RT. No trace of desired product by LCMS. The reaction was not progressed further.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-512d2d9fb0454cb39e6db5113f92b34b |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
