関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 1-Chloronaphthalene | HCID 7003 | — |
| 反応物 | 3,4-Difluoroaniline | HCID 77469 | — |
| 生成物 | 3,4-Difluorophenyl isocyanate | HCID 2734708 | — |
反応手順
At -10° to 0° and while stirring, 120 g of 3,4-difluoroaniline (J. Chem. Soc., 73, 5884-5, 1951) is metered into a solution of 180 parts by weight of phosgene in 1,100 parts by weight of chloronaphthalene. The reaction mixture is then slowly heated to 150° C. while passing in additional phosgene, and phosgenated for 2 hours at this temperature. Excess phosgene is expelled with nitrogen and the isocyanate distilled from the solution; b.p. (30 mm Hg): 79°-85° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04131751 |
|---|
| 出典データセット | uspto-grants-1978_12 |
|---|
| ORD ID | ord-0948dd6266ce475dbffc5549c083ee48 |
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| 出典メモ | uspto-grants-1978_12 |
|---|
