関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-5-bromo-4-methoxypyrimidine | HCID 45036937 | — |
| 反応物 | 1-Fluoro-2-iodo-4-(trifluoromethyl)benzene | HCID 46735235 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-4-methoxypyrimidin-2-amine | HCID 106998904 | 0% |
反応手順
To a microwave vial was added a mixture of 5-bromo-4-methoxypyrimidin-2-amine (0.513 g, 2.51 mmol), diacetoxypalladium (0.055 g, 0.245 mmol), tri(furan-2-yl)phosphine (0.126 g, 0.54 mmol), 1-fluoro-2-iodo-4-(trifluoromethyl)benzene (0.98 g, 3.38 mmol) and toluene (17 mL) under inert atmosphere. The reaction mixture was sealed and heated at 90 °C under 15h. The LCMS indicated no reaction ??? The sample discarded.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-f903bfa68e6e46fb8291b98645969acd |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
