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Ethyl Acrylate → 4-Oxo-4-(thiophen-3-yl)butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acrylate | HCID 8821 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| 反応物 | 4-Morpholinyl(3-thienyl)acetonitrile | HCID 13041699 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Oxo-4-(thiophen-3-yl)butanoic acid | HCID 315657 | — |
反応手順
As for Example 6, 99 g. of 3-thiophenecarboxaldehyde is converted to α-(3-thienyl)-4-morpholineacetonitrile (137 g.; m.p. 85°-87° C.). The preceding compound 50.5 g. is reacted with 100 ml. of ethyl acrylate in 500 ml. of tetrahydrofuran in the presence of 50 ml. of 30% potassium hydroxide in ethanol. The solvent is removed from the reaction mixture and the residue is heated with 6 N hydrochloric acid to give 3-(3-thenoyl)propionic acid. As for Example 1, the preceding compound is converted to the product of the Example to give a glass.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04342691 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-403956225eee4c4c88d9995150e86130 |
| 出典メモ | uspto-grants-1982_08 |