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Hydrochloric Acid → 3-(1-Methyl-2-pyrrolylcarbonyl)propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl Acrylate | HCID 8821 | — |
| 反応物 | 1-Methyl-1H-pyrrole-2-carbaldehyde | HCID 14504 | — |
| 反応物 | (1-methyl-1H-pyrrol-2-yl)(morpholin-4-yl)acetonitrile | HCID 20529962 | — |
| 生成物 | 3-(1-Methyl-2-pyrrolylcarbonyl)propionic acid | HCID 12504054 | — |
反応手順
As for Example 6, 1-methyl-2-pyrrolecarboxaldehyde is converted to α-(1-methyl-2-pyrrolyl)-4-morpholineacetonitrile. The preceding compound is reacted with ethyl acrylate and the resulting 1,4-addition product is heated at 100° C. with 6 N hydrochloric acid to give 3-(1-methyl-2-pyrrolylcarbonyl)propionic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04342691 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-8c85ff01860947939b7ac9ab9180f46c |
| 出典メモ | uspto-grants-1982_08 |