2-(4-Chlorophenyl)ethylamine → HCID 178512614、化合物

HRID 66578

反応式

HRID 66578 の反応式
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17]3[C:20](=O)[C:19](=[O:22])[C:18]=3[O:23]C)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH2:34])=[CH:28][CH:27]=1>CO.C(Cl)(Cl)Cl>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17]3[C:18](=[O:23])[C:19](=[O:22])[C:20]=3[NH:34][CH2:33][CH2:32][C:29]3[CH:30]=[CH:31][C:26]([Cl:25])=[CH:27][CH:28]=3)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

参加物

4

反応物 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 178493670HCID 178493670、化合物

生成物 1

HCID 178512614HCID 178512614、化合物

試薬・触媒・溶媒 1

HCID 21584188Chloroform methanol溶媒

実験手順

To a solution of 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-methoxycyclobutene-3,4-dione (0.19 g.) in 35 ml. of methanol/chloroform (50:50 v/v) was added 2-(p-chlorophenyl)ethylamine (0.18 g.) and the resulting mixture allowed to stand at room temperature for 5 hours. After heating under reflux for 2.5 hours the reaction mixture was cooled and the precipitated buff-coloured solid collected to give 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-[2-(p-chlorophenyl)ethylamino]cyclobutene-3,4-dione. The n.m.r. spectrum in d6 dimethylsulphoxide included resonances at 1.2 (m), 1.8 (m), 2.5 (t), 3.7 (m), 6.24 (s), 6.78 (br s).

後処理

  1. temperatureAfter heating
  2. temperatureunder reflux for 2.5 hours the reaction mixture
  3. temperaturewas cooled
  4. customthe precipitated buff-coloured solid collected

出典と根拠

ORDレコード
ord-4317b11e0d0c4be0b00fb8b6f1b315db
出典データセット
uspto-grants-1982_08
特許番号
US04342765

関連ノート

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