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Potassium Carbonate → alpha-[(6-Acetyl-2-methoxycarbonylphenyl)oxy]-gamma-butyrolactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2(3H)-Furanone, 3-bromodihydro- | HCID 95463 | — |
| 反応物 | Methyl 3-acetyl-2-hydroxybenzoate | HCID 13037297 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | alpha-[(6-Acetyl-2-methoxycarbonylphenyl)oxy]-gamma-butyrolactone | HCID 13037298 | — |
反応手順
To a mixture of methyl 3-acetylsalicylate (5.8 g) and potassium carbonate (10.4 g) in acetone (200 ml) was added α-bromo-γ-butyrolactone (12.5 g) under stirring, and the mixture was refluxed for 11 hours. The insolubles were filtered off and the filtrate was concentrated under reduced pressure. The residue was subjected to chromatography on silica gel eluting with chloroform. By the above procedure, there was obtained α-[(6-acetyl-2-methoxycarbonylphenyl)oxy]-γ-butyrolactone as pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04342779 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-6d6d16c133d14dc98d2670831a546e4a |
| 出典メモ | uspto-grants-1982_08 |