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HRID 66593作成日:2026年10月25日

1-Methylindole → 5-Hydroxy-5-(1-methyl-3-indolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

https://huagongshe.com/reaction/66593

反応式

関与物質

役割名称HCID仕込み量
反応物1-MethylindoleHCID 11781—
反応物2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrateHCID 16723—
溶媒EthanolHCID 702—
生成物5-Hydroxy-5-(1-methyl-3-indolyl)-2,4,6-(1H,3H,5H)pyrimidinetrioneHCID 21271250—

反応手順

Alloxan hydrate (1.6 g., 0.01 mole) 1-methylindole (1.3 g., 0.01 mole) and ethanol (50 ml.) was combined and the mixture refluxed for 0.5 hour, then concentrated to half-volume, diluted with water and the resulting product recovered by filtration [2.7 g., Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US04342771
出典データセットuspto-grants-1982_08
ORD IDord-b905210002c446778598a5214583d97f
出典メモuspto-grants-1982_08