Hydrochloric Acid → 1-Fluoro-3-(3-methoxyphenyl)-2-propanone
反応式
C([O:3][C:4](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[CH2:5][F:6])C.Cl>C(OCC)C>[F:6][CH2:5][C:4](=[O:3])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1参加物
4
実験手順
2-Ethoxy-1-fluoro-3-(3-methoxyphenyl)prop-2-ene (8.40 g, 0.040 mol) is stirred with a saturated solution of hydrogen chloride in diethyl ether (80 ml) overnight. The ether layer is separated, washed with water, dried (MgSO4) and filtered. Concentration of the solvent affords 1-fluoro-3-(3-methoxyphenyl)-2-propanone (7.200 g); NMR (CDCl3): 3.73 ppm (m, 5H); 4.77 ppm (d, JHF =48 Hz, 2H); 6.57-7.33 ppm (m, 4H).
後処理
- customThe ether layer is separated
- washwashed with water
- dry with materialdried (MgSO4)
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-e14898658dde410eba4a7fd2917d48e1
- 出典データセット
- uspto-grants-1982_08
- 特許番号
- US04342780
反応ノート
読み込み中…