Phosphorus oxychloride → 5-chloro-6-n-propyl-3-methoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide

反応式

P(Cl)(Cl)(Cl)(Cl)Cl.[CH2:7]([N:10]1[S:15](=[O:17])(=[O:16])[NH:14][C:13]([O:18][CH3:19])=[N:12][C:11]1=O)[CH2:8][CH3:9].P(Cl)(Cl)([Cl:23])=O>>[Cl:23][C:11]1[N:10]([CH2:7][CH2:8][CH3:9])[S:15](=[O:17])(=[O:16])[N:14]=[C:13]([O:18][CH3:19])[N:12]=1

参加物

反応物 3

HCID 24813Phosphorus oxychloride

HCID 24819Phosphorus pentachloride

HCID 178456603HCID 178456603、化合物

生成物 1

HCID 129179865-chloro-6-n-propyl-3-methoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide

反応条件

温度: 110 °C

実験手順

50 parts of phosphorus pentachloride were added to a stirred mixture of 44 parts of 6-n-propyl-3-methoxy-6H-1,2,4,6-thiatriazin-5-one-1,1-dioxide and 268 parts of phosphorus oxychloride at 22° C., and the batch was heated to 110° C. in the course of 20 minutes. After 7 hours' stirring under reflux, it was evaporated down under reduced pressure, giving 45 parts of oily 5-chloro-6-n-propyl-3-methoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide; NMR (CDCl3): N-CH2 4.0-4.28.

後処理

temperatureunder reflux
customit was evaporated down under reduced pressure

出典と根拠

ORDレコード: ord-6367f4796fb141b6812638ff7dcdeb46
出典データセット: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04343648

反応ノート

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