Methyl acetoacetate → HCID 178429333、化合物

HRID 66716

反応式

HRID 66716 の反応式
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([NH2:5])=[NH:4].C[O:9][C:10](=O)[CH2:11][C:12]([CH3:14])=O.C(=O)([O-])[O-].[K+].[K+]>O>[OH:9][C:10]1[CH:11]=[C:12]([CH3:14])[N:5]=[C:3]([C:2]([Cl:7])([Cl:6])[Cl:1])[N:4]=1

参加物

5

反応物 3

HCID 7757Methyl acetoacetateHCID 11430Potassium CarbonateHCID 356082,2,2-Trichloroethanimidamide

生成物 1

HCID 178429333HCID 178429333、化合物収率 46%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 44.4 g (0.28 mole) trichloroacetamidine, 32.0 g (0.28 mole) methylacetoacetate, 37.5 g (0.28 mole) potassium carbonate, and 450 ml water was stirred for 3 days. A trace of solid was removed by filtration and the filtrate was made acidic with hydrochloric acid. The product precipitated out to give 28.9 g (46% yield; mp 173°-174° C.). The structure was confirmed via mp*, infrared and elemental analysis.

後処理

  1. customA trace of solid was removed by filtration
  2. customThe product precipitated out
  3. customto give 28.9 g (46% yield; mp 173°-174° C.)

出典と根拠

ORDレコード
ord-71fc33f291614c5e91f54f39326cf623
出典データセット
uspto-grants-1982_08
特許番号
US04343803

関連ノート

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