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Dimethyl Sulfoxide → 2-(4-Chlorophenoxy)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 4-Chlorophenol | HCID 4684 | — |
| 反応物 | Chloroacetonitrile | HCID 7856 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(4-Chlorophenoxy)acetonitrile | HCID 306444 | 92.5% |
反応手順
A mixture of 64.25 g of 4-chlorophenol, 98 g of anhydrous potassium carbonate, 40 g of chloroacetonitrile and 100 ml of dimethyl sulfoxide was heated with stirring in a 500 ml round-bottomed three-necked flask at 70°-80° C. for 3.0 hours. The reaction mixture was then poured into ice and water. After the ice melted, the mixture was filtered and the product washed well with water which gave 77.5 g of 4-chlorophenoxyacetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343809 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-9c18c5a5f562428fb1f2d2a6984cc88c |
| 出典メモ | uspto-grants-1982_08 |