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Benzyl Alcohol → 2-(Benzyloxy)-3-chloropyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2,3-Dichloropyrazine | HCID 78575 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-(Benzyloxy)-3-chloropyrazine | HCID 20528929 | — |
反応手順
Sodium hydride (0.10 mole) is added to 0.10 mole of benzyl alcohol in 100 ml. dry benzene and the mixture is refluxed 1-2 hours. The cooled solution is treated with 0.10 mole of 2,3-dichloropyrazine in 100 ml. of benzene. The mixture is refluxed for 20-60 hours, cooled, washed with water, dried, and evaporated and the product distilled in vacuo to give 2-chloro-3-benzyloxypyrazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343802 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-225288ec1c894972937e9a596b5c7a79 |
| 出典メモ | uspto-grants-1982_08 |