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Sulfuric Acid → 5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1-(3-Chlorophenyl)propan-2-one | HCID 2734097 | — |
| 反応物 | (4-(Benzyloxy)phenyl)hydrazine monohydrochloride | HCID 3016725 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole | HCID 20529201 | — |
反応手順
An amount of 11.7 g (47 m mole) of 4-benzyloxyphenylhydrazine-hydrochloride and 6.39 g (38 m mole) of (3-chlorophenyl)-acetone was dissolved in 35 ml of absolute ethanol, and after addition of 2.7 ml of concentrated sulfuric acid the mixture was refluxed for five hours. After the ethanol was distilled off, the residue was mixed with water and extracted with chloroform. The extracts were dried over sodium sulfate and evaporated. The evaporation residue was purified by chromatography on silicagel by using toluene as solvent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343811 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-f34ce889d3be4b0e8cb3c4cfd7a91c36 |
| 出典メモ | uspto-grants-1982_08 |