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Sodium hydride → 5-(2-ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid ethylester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 5-bromovalerate | HCID 84580 | — |
| 反応物 | 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester | HCID 4777862 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(2-ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid ethylester | HCID 54250733 | — |
反応手順
An amount of 23.5 g (63.3 m mole) of 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester in absolute dimethylformamide was mixed with 3.0 g (63.3 m mole) of 50% sodium hydride. After 30 minutes, 13.2 g (63.3 m mole) of 5-bromo-valeric acid ethylester were added, and the mixture was stirred for three days. After evaporation, the residue obtained was chromatographed on silicagel (solvent: toluene/acetone (20.1)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343811 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-2380d4f359754994b05163591b874988 |
| 出典メモ | uspto-grants-1982_08 |