Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[2-Isopropyl-3-(4-pyridyl)-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

反応式

[CH:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[CH:10][C:9]([OH:19])=[CH:8][CH:7]=2)([CH3:3])[CH3:2].[CH2:20]([O:22][C:23](=[O:28])[C:24](Br)([CH3:26])[CH3:25])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:28])[C:24]([O:19][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[C:12]2[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)([CH3:26])[CH3:25])[CH3:21]

参加物

反応物 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl ester

HCID 205291092-isopropyl-3-(4-pyridyl)-1H-indole-5-ol

生成物 1

HCID 542220782-[2-Isopropyl-3-(4-pyridyl)-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

実験手順

The above compound was prepared from 2-isopropyl-3-(4-pyridyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

出典と根拠

ORDレコード: ord-14379d4110c14e7f809d191796510e0e
出典データセット: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04343811

反応ノート

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