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1-Phenethylpiperazine → (1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenethylpiperazine | HCID 79214 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| 反応物 | Indole-4-carboxylic acid | HCID 595229 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | (1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride | HCID 131725875 | 100.1% |
反応手順
A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084143B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d902f388819647f19c93534fd4a3ba09 |
| 出典メモ | uspto-grants-2006_08 |