Potassium Carbonate → 2-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid

HRID 66889

反応式

HRID 66889 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]([CH2:19][CH2:20][CH3:21])[C:10]=2[CH3:22])=[CH:5][CH:4]=1.Br[C:24]([CH3:29])([CH3:28])[C:25]([OH:27])=[O:26].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][C:24]([CH3:29])([CH3:28])[C:25]([OH:27])=[O:26])[CH:16]=3)[N:11]([CH2:19][CH2:20][CH3:21])[C:10]=2[CH3:22])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 749242-Bromo-2-methylpropanoic acidHCID 205291893-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol

生成物 1

HCID 205290812-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 5.9 g (0.02 mole) of 3-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol, 5.1 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid, and 15 g of potassium carbonate was refluxed in 100 ml of acetone for 48 hours. The acetone was removed in vacuo, and the residue was acidified with 2N hydrochloric acid. After extraction with ethyl acetate, the extracts were dried over sodium sulfate and evaporated. The residue obtained was purified by chromatography on silicagel (eluant: chloroform/methanol (9:1)).

後処理

  1. customThe acetone was removed in vacuo
  2. extractionAfter extraction with ethyl acetate
  3. dry with materialthe extracts were dried over sodium sulfate
  4. customevaporated
  5. customThe residue obtained
  6. customwas purified by chromatography on silicagel (eluant: chloroform/methanol (9:1))

出典と根拠

ORDレコード
ord-acfe4b0ec0cf4652b3bbfe920251e012
出典データセット
uspto-grants-1982_08
特許番号
US04343811

関連ノート

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