2-Bromo-2-methylpropanoic acid → Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl-

HRID 66890

反応式

HRID 66890 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=3)[N:10]([CH3:18])[C:9]=2[CH3:19])=[CH:4][CH:3]=1.Br[C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23]>C(Cl)(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])[CH:15]=3)[N:10]([CH3:18])[C:9]=2[CH3:19])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 749242-Bromo-2-methylpropanoic acidHCID 205291643-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol

生成物 1

HCID 3059432Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl-

試薬・触媒・溶媒 1

HCID 21584188Chloroform methanol溶媒

実験手順

A mixture of 5.4 g (0.02 mole) of 3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol, and 5.1 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid was heated for two hours to 90°-130° C. Subsequently the mixture was taken up in chloroform/methanol (8:2) and chromatographed on silicagel. The evaporation residue of the eluate was stirred with cyclohexane and suction filtered.

後処理

  1. temperaturewas heated for two hours to 90°-130° C
  2. customchromatographed on silicagel
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-ada52e101a4645c99cec87490df7da89
出典データセット
uspto-grants-1982_08
特許番号
US04343811

関連ノート

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