化工社化工社 化学情報印刷レポート · 研究参考用
Toluene → 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 2-Methylbenzoyl chloride | HCID 70276 | — |
| 反応物 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041514 | 35.1% |
反応手順
A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. Following recrystallization for toluene, 11.8 g (35% yield) of pure product was otained; m.p. 170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343945 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-40e39dbc987749c18435765ac008b42e |
| 出典メモ | uspto-grants-1982_08 |