化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylbenzoyl Chloride → 5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 反応物 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041516 | — |
反応手順
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 8.0 g (0.05 mole) 4-toluoyl chloride in 250 ml toluene was heated at reflux for 20 hours. Unreacted amino compound was removed by cooling the reaction mixture and filtering the precipitate. Concentration of the filtrate in vacuo gave the crude product, which was purified by recrystallization from cyclohexane. Yield was 9.1 g (27%); m.p. 127° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343945 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-941fe4c55371425b876f0a5cbd9052c1 |
| 出典メモ | uspto-grants-1982_08 |