化工社化工社 化学情報印刷レポート · 研究参考用
p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Anisoyl chloride | HCID 7477 | — |
| 反応物 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041517 | — |
反応手順
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343945 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-c5e879964bea48bfb1cb9bbca35b987c |
| 出典メモ | uspto-grants-1982_08 |