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Benzoyl chloride, 3-nitro- → 5-(3-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 反応物 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 5-(3-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041518 | 69.1% |
反応手順
A solution of 21.8 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 18.6 g (0.1 mole) 3-nitrobenzoyl chloride in 250 ml xylene was heated at reflux for 20 hours. Unreacted starting amino compound was recovered by cooling the reaction mixture and filtering the resulting precipitate. The filtrate was concentrated in vacuo and the residue recrystallized from xylene. After washing with petroleum ether, 25.4 g (69% yield) of pure product was obtained; m.p. 198° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343945 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-de6e7a9e35cd4ea48025e0a704ebed64 |
| 出典メモ | uspto-grants-1982_08 |