4-Nitrobenzoyl chloride → 5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66940ノート

反応式

HRID 66940 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[N+:11]([C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1)([O-:13])=[O:12]>C1(C)C=CC=CC=1>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([NH:1][C:2]2[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=2)=[O:19])=[CH:21][CH:22]=1)([O-:13])=[O:12]

参加物

4

反応物 2

HCID 85024-Nitrobenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

生成物 1

HCID 130415195-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole収率 73.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

後処理

  1. temperatureat reflux for 20 hours
  2. customthe crude product precipitated from the reaction mixture
  3. customwas isolated by filtration
  4. washAfter washing with hexane

出典と根拠

ORDレコード
ord-cf535115d4a34be684be0052ae84a514
出典データセット
uspto-grants-1982_08
特許番号
US04343945

反応ノート

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