関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,5-Dinitrobenzoyl chloride | HCID 7432 | — |
| 反応物 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(3,5-Dinitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041520 | 85% |
反応手順
A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.6 g (0.055 mole) 3,5-dinitrobenzoyl chloride in 200 ml toluene was refluxed for 20 hours. The crude product precipitated from the reaction mixture upon cooling to -10° C. After isolation by filtration, the residue was washed with hot petroleum ether and finally recrystallized from methylene chloride to give 17.5 g (85% yield) of pure product; m.p. 197° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04343945 |
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| 出典データセット | uspto-grants-1982_08 |
|---|
| ORD ID | ord-8e93b465b8fa4b39bec5f67f154ba6ef |
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| 出典メモ | uspto-grants-1982_08 |
|---|
